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CBDV Moderates Fragile X Syndrome Progression According To French Study

Cannabis Flower Plant Garden

The cannabis plant is made up of dozens of cannabinoids, with two of the most well-known examples being tetrahydrocannabinol (THC) and cannabidiol (CBD). Both cannabinoids are the focus of a growing body of peer-reviewed research, and rightfully so.

However, in recent years other lesser-known cannabinoids have risen in popularity within the international research community, including cannabidivarin (CBDV). CBDV, much like CBD, does not induce intoxication.

Researchers in France recently examined CBDV and its potential as a treatment for Fragile X Syndrome. Below is more information about the study via a news release from NORML:

Bordeaux, France: The administration of the cannabinoid cannabidivarin (CBDV) moderates the progression of Fragile X syndrome (FXS), according to preclinical data published in the journal Cells.

An international team of researchers from France, Italy, the United Kingdom, and the United States assessed the efficacy of CBDV treatment in a mouse model of Fragile X syndrome. FXS is a genetic disorder resulting in developmental delays, learning disabilities, and behavioral problems, such as aggression and attention deficits.

Investigators reported that CBDV administration during adolescence prevented cognitive and behavioral changes in a manner similar to other pharmacological treatments. By contrast, CBDV’s effects were “marginal” when the compound was administered during adulthood.

They determined: “Overall, these data demonstrate that CBDV, when administered chronically and starting at juvenile age, holds a solid therapeutic potential for FXS as it prevented the most relevant behavioral alterations shown by … mice. Early timing and chronic duration of treatment appear as critical determinants to ensure the beneficial effects of CBDV.”

The study’s authors concluded, “These results thus encourage future clinical studies using phytocannabinoids for treating not only FXS but also other neurodevelopmental disorders.”

Parents and caregivers of children with FXS patients report using CBD for symptom management. The administration of a transdermal gel containing CBD has been shown to be safe and effective in FSX patients in randomized, placebo-controlled clinical trials.

Full text of the study, “Early administration of the phytocannabinoid cannabidivarin prevents the neurobehavioral abnormalities associated with the Fmr1-KO mouse model of Fragile X syndrome,” appears in Cells.